Protein Details: Potassium channel subfamily K member 6

Protein ID

ICDB_Pro_1713

Protein Name

Potassium channel subfamily K member 6

Gene Name

KCNK6; TOSS; TWIK2

Organism

Homo sapiens (Human)

Length

313 amino acids

AlphaFoldDB

AF-Q9Y257-F1-model_v4.pdb

Function

Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.

Sequence

MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALDAFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQLSASSHTDYASIPR

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Birk-Barel Syndrome

Location

Widespread expression;detected in all tissues tested except for skeletal muscle. Strongest expression in placenta;pancreas;heart;colon and spleen;lower levels detected in peripheral blood leukocytes;lung;liver;kidney and thymus. Lowest expression detected in brain. Lowest expression detected in brain. Lowest expression detected in brain.

DOI ID

10.1016/s0014-5793(99)00495-0; 10.1074/jbc.274.12.7887; 10.1074/jbc.m003755200; 10.1101/gr.2596504

RefSeq

NP_004814.1 [Q9Y257-1]; XP_011525828.1;